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1

A brief history of melanoma

Rebecca, Vito W., Sondak, Vernon K., Smalley, Keiran S.M.

Journal:

Melanoma Research

Year:

2012

Language:

english

File:

PDF, 272 KB

english, 2012

2

The Blood Brain Barrier and BRAF inhibitors: Implications for patients with melanoma brain metastases

Smalley, Keiran S.M., Forsyth, Peter A.

Journal:

Pharmacological Research

Year:

2017

Language:

english

File:

PDF, 387 KB

english, 2017

3

BRAF-MEK inhibition in melanoma brain metastases: a new hope

Forsyth, Peter A, Smalley, Keiran S M, Sondak, Vernon K

Journal:

The Lancet Oncology

Year:

2017

Language:

english

File:

PDF, 153 KB

english, 2017

4

Improved survival of patients with melanoma brain metastases in the era of targeted BRAF and immune checkpoint therapies

Sloot, Sarah, Chen, Yian A., Zhao, Xiuhua, Weber, Jamie L., Benedict, Jacob J., Mulé, James J., Smalley, Keiran S., Weber, Jeffrey S., Zager, Jonathan S., Forsyth, Peter A., Sondak, Vernon K., Gibney,

Journal:

Year:

2017

Language:

english

File:

PDF, 323 KB

english, 2017

5

Get with the Program! Stemness and Reprogramming in Melanoma Metastasis

Faião-Flores, Fernanda, Smalley, Keiran S.M.

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 295 KB

english, 2018

6

Reply to Improving the survival of patients with American Joint Committee on Cancer stage III and IV melanoma

Sloot, Sarah, Chen, Yian A., Zhao, Xiuhua, Weber, Jamie L., Benedict, Jacob J., Mulé, James J., Smalley, Keiran S., Weber, Jeffrey S., Zager, Jonathan S., Forsyth, Peter A., Sondak, Vernon K., Gibney,

Journal:

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

7

ITCH as a potential therapeutic target in human cancers

Yin, Qing, Wyatt, Clayton J., Han, Tao, Smalley, Keiran S.M., Wan, Lixin

Journal:

Seminars in Cancer Biology

Year:

2020

Language:

english

File:

PDF, 1.16 MB

english, 2020

8

Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes

Jasna Maksimoska, Douglas S. Williams, G. Ekin Atilla-Gokcumen, Keiran S. M. Smalley, Patrick J. Carroll, Richard D. Webster, Panagis Filippakopoulos, Stefan Knapp, Meenhard Herlyn, Eric Meggers

Journal:

Chemistry - A European Journal

Year:

2008

Language:

english

File:

PDF, 447 KB

english, 2008

9

Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects

Keiran S.M. Smalley, Tim G. Eisen

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 718 KB

english, 2002

10

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

Keiran S.M. Smalley

Journal:

International Journal of Cancer

Year:

2003

Language:

english

File:

PDF, 95 KB

english, 2003

11

Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells

Keiran S.M. Smalley, Tim G. Eisen

Journal:

International Journal of Cancer

Year:

2003

Language:

english

File:

PDF, 478 KB

english, 2003

12

Integrating tumor-initiating cells into the paradigm for melanoma targeted therapy

Keiran S.M. Smalley, Meenhard Herlyn

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 144 KB

english, 2009

13

The Great Escape: Another Way for Melanoma to Leave Physiological Control?

Smalley, Keiran S. M., Herlyn, Meenhard

Journal:

The Journal of Investigative Dermatology

Year:

2003

Language:

english

File:

PDF, 47 KB

english, 2003

14

Book reviews

Julie Osborne, Keiran Smalley

Journal:

Molecular Biotechnology

Year:

2002

Language:

english

File:

PDF, 75 KB

english, 2002

15

Loitering with Intent: New Evidence for the Role of BRAF Mutations in the Proliferation of Melanocytic Lesions

Smalley, Keiran S. M., Herlyn, Meenhard

Journal:

The Journal of Investigative Dermatology

Year:

2004

Language:

english

File:

PDF, 39 KB

english, 2004

16

Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy?

Keiran SM Smalley, Herlyn Meenhard

Journal:

Experimental Dermatology

Year:

2006

Language:

english

File:

PDF, 444 KB

english, 2006

17

Adhesion, migration and communication in melanocytes and melanoma

Nikolas K. Haass, Keiran S. M. Smalley, Ling Li, Meenhard Herlyn

Journal:

Pigment Cell & Melanoma Research

Year:

2005

Language:

english

File:

PDF, 769 KB

english, 2005

18

Ipilimumab

Sondak, Vernon K., Smalley, Keiran S. M., Kudchadkar, Ragini, Grippon, Seden, Kirkpatrick, Peter

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 221 KB

english, 2011

19

Targeting Intracellular Signaling Pathways as a Novel Strategy in Melanoma Therapeutics

KEIRAN S.M. SMALLEY, MEENHARD HERLYN

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 959 KB

english, 2005

20

The Role of Altered Cell–Cell Communication in Melanoma Progression

Nikolas K. Haass, Keiran S.M. Smalley, Meenhard Herlyn

Journal:

Journal of Molecular Histology

Year:

2004

Language:

english

File:

PDF, 201 KB

english, 2004

21

Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells

Dong Fang, Kim Leishear, Thiennga K. Nguyen, Rena Finko, Kun Cai, Mizuho Fukunaga, Ling Li, Patricia A. Brafford, Angela N. Kulp, Xiaowei Xu, Keiran S. M. Smalley, Meenhard Herlyn

Journal:

Year:

2006

Language:

english

File:

PDF, 1.20 MB

english, 2006

22

Introduction to the Biochemical Pharmacology special issue on targeted cancer therapy

Keiran S.M. Smalley

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 61 KB

english, 2010

23

Methods for investigation of targeted kinase inhibitor therapy using chemical proteomics and phosphorylation profiling

Bin Fang, Eric B. Haura, Keiran S. Smalley, Steven A. Eschrich, John M. Koomen

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 452 KB

english, 2010

24

Rewired ERK-JNK Signaling Pathways in Melanoma

Pablo Lopez-Bergami, Conway Huang, James S. Goydos, Dana Yip, Menashe Bar-Eli, Meenhard Herlyn, Keiran S.M. Smalley, Alka Mahale, Alexey Eroshkin, Stuart Aaronson, Ze'ev Ronai

Journal:

Year:

2007

Language:

english

File:

PDF, 1.36 MB

english, 2007

25

Selective evolutionary pressure from the tissue microenvironment drives tumor progression

Keiran S.M. Smalley, Patricia A. Brafford, Meenhard Herlyn

Journal:

Seminars in Cancer Biology

Year:

2005

Language:

english

File:

PDF, 323 KB

english, 2005

26

The Current State of Targeted Therapy in Melanoma: This Time It's Personal

Keiran S.M. Smalley, Grant A. McArthur

Journal:

Seminars in Oncology

Year:

2012

Language:

english

File:

PDF, 753 KB

english, 2012

27

The Pivotal Role of Phosphoinositide-3 Kinase in the Human Somatostatin sst4 Receptor-Mediated Stimulation of p44/p42 Mitogen-Activated Protein Kinase and Extracellular Acidification

Keiran S.M. Smalley, Wasyl Feniuk, Lynda A. Sellers, Patrick P.A. Humphrey

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 152 KB

english, 1999

28

Somatic genetics and targeted therapies for cutaneous melanoma

Keith Flaherty, Keiran S.M. Smalley

Journal:

Update on Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 163 KB

english, 2008

29

Up-Regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-Cadherin and Contributes to Invasion and Adhesion

Keiran S.M. Smalley, Patricia Brafford, Nikolas K. Haass, Johanna M. Brandner, Eric Brown, Meenhard Herlyn

Journal:

The American Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 2.57 MB

english, 2005

30

The involvement of p38 mitogen-activated protein kinase in the α-melanocyte stimulating hormone (α-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells

Keiran Smalley, Tim Eisen

Journal:

Year:

2000

Language:

english

File:

PDF, 270 KB

english, 2000

31

Dysregulation of Claudin-7 Leads to Loss of E-Cadherin Expression and the Increased Invasion of Esophageal Squamous Cell Carcinoma Cells

Mercedes Lioni, Patricia Brafford, Claudia Andl, Anil Rustgi, Wafik El-Deiry, Meenhard Herlyn, Keiran S.M. Smalley

Journal:

The American Journal of Pathology

Year:

2007

Language:

english

File:

PDF, 1.69 MB

english, 2007

32

Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report

Vernon K. Sondak, Keiran Smalley

Journal:

Pigment Cell & Melanoma Research

Year:

2009

Language:

english

File:

PDF, 34 KB

english, 2009

33

Preclinical and clinical development of targeted therapy in melanoma: attention to schedule

Keith T. Flaherty, Keiran S. M. Smalley

Journal:

Pigment Cell & Melanoma Research

Year:

2009

Language:

english

File:

PDF, 61 KB

english, 2009

34

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

John T. Lee, Ling Li, Patricia A. Brafford, Marcia van den Eijnden, Molly B. Halloran, Katrin Sproesser, Nikolas K. Haass, Keiran S.M. Smalley, James Tsai, Gideon Bollag, Meenhard Herlyn

Journal:

Pigment Cell & Melanoma Research

Year:

2010

Language:

english

File:

PDF, 695 KB

english, 2010

35

Meeting report from the 2011 international melanoma congress, Tampa, Florida

Keiran S. M. Smalley, Andrew E. Aplin, Keith T. Flaherty, Christoph Hoeller, Anja K. Bosserhoff, Nikolas K. Haass, Marcus Bosenberg, Antoni Ribas, Raymond Barnhill, Ragini Kudchadkar, Jane L. Messina

Journal:

Pigment Cell & Melanoma Research

Year:

2012

Language:

english

File:

PDF, 8.18 MB

english, 2012

36

Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma

Inna V. Fedorenko, Kim H.T. Paraiso, Keiran S.M. Smalley

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 582 KB

english, 2011

37

The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma–Induced Angiogenesis

Kazuhiro Noma, Keiran S.M. Smalley, Mercedes Lioni, Yoshio Naomoto, Noriaki Tanaka, Wafik El–Deiry, Alastair J. King, Hiroshi Nakagawa, Meenhard Herlyn

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 6.66 MB

english, 2008

38

Life ins't flat: Taking cancer biology to the next dimension

Keiran S. M. Smalley, Mercedes Lioni, Meenhard Herlyn

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2006

Language:

english

File:

PDF, 963 KB

english, 2006

39

Tumor heterogeneity and strategies to overcome kinase inhibitor resistance in cancer: lessons from melanoma

Rebecca, Vito W, Smalley, Keiran SM

Journal:

Expert Opinion on Investigational Drugs

Year:

2011

Language:

english

File:

PDF, 248 KB

english, 2011

40

Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma

Gibney, Geoffrey T., Messina, Jane L., Fedorenko, Inna V., Sondak, Vernon K., Smalley, Keiran S. M.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2013

Language:

english

File:

PDF, 661 KB

english, 2013

41

Fibroblast-mediated drug resistance in cancer

Paraiso, Kim H.T., Smalley, Keiran S.M.

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 984 KB

english, 2013

42

Melanoma genotypes and phenotypes get personal

Pimiento, Jose M, Larkin, Eileen M, Smalley, Keiran SM, Wiersma, Ginger L, Monks, Noel R, Fedorenko, Inna V, Peterson, Chelsea A, Nickoloff, Brian J

Journal:

Laboratory Investigation

Year:

2013

Language:

english

File:

PDF, 258 KB

english, 2013

43

Mutant BRAF: A Novel Mediator of Microenvironmental Escape in Melanoma?

Smalley, Keiran S M

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 95 KB

english, 2013

44

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

Flach, Edward H., Rebecca, Vito W., Herlyn, Meenhard, Smalley, Keiran S. M., Anderson, Alexander R. A.

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 5.36 MB

english, 2011

45

In Vivo and in Silico Pharmacokinetics and Biodistribution of a Melanocortin Receptor 1 Targeted Agent in Preclinical Models of Melanoma

Tafreshi, Narges K., Silva, Ariosto, Estrella, Veronica C., McCardle, Timothy W., Chen, Tingan, Jeune-Smith, Yolaine, Lloyd, Mark C., Enkemann, Steven A., Smalley, Keiran S. M., Sondak, Vernon K., Vag

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

46

Resistance to Raf inhibition in cancer

Haarberg, H. Eirik, Smalley, Keiran S.M.

Journal:

Drug Discovery Today: Technologies

Year:

2014

Language:

english

File:

PDF, 644 KB

english, 2014

47

Targeted therapy in melanoma

Kudchadkar, Ragini R., Smalley, Keiran S.M., Glass, L. Frank, Trimble, James S., Sondak, Vernon K.

Journal:

Clinics in Dermatology

Year:

2013

Language:

english

File:

PDF, 698 KB

english, 2013

48

In vitro three-dimensional tumor microenvironment models for anticancer drug discovery

Smalley, Keiran SM, Lioni, Mercedes, Noma, Kazuhiro, Haass, Nikolas K, Herlyn, Meenhard

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

49

Life Isn't Flat: Taking Cancer Biology to the Next Dimension

Keiran S. M. Smalley, Mercedes Lioni and Meenhard Herlyn

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2006

Language:

english

File:

PDF, 451 KB

english, 2006

50

Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

Xie, Peng, Williams, Douglas S., Atilla-Gokcumen, G. Ekin, Milk, Leslie, Xiao, Min, Smalley, Keiran S. M., Herlyn, Meenhard, Meggers, Eric, Marmorstein, Ronen

Journal:

ACS Chemical Biology

Year:

2008

Language:

english

File:

PDF, 2.97 MB

english, 2008